T cells recognize recent SARS-CoV-2 variants (NIAID, Johns Hopkins University, & ImmunoScape Collaboration)

ImmunoScape has continued its COVID-19 collaboration with NIAID and the Johns Hopkins University to better understand if the CD8+ T-cell responses from COVID-19 recovered individuals still recognize the major SARS-CoV-2 variants. Out of 45 mutations assessed from the SA, UK and Brazil variants, only one mutation within the SA variant, B.1.351 Spike protein overlapped with a single low-prevalence CD8+ epitope T cell response. These findings suggest that virtually all the anti-SARS-CoV-2 CD8+ T-cell responses induced by COVID-19 infection in our recovered individuals should recognize these newly described variants.

These findings were published in Open Forum Infectious Diseases DOI: 10.1093/ofid/ofab143 (2021)

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