Careers

• Protein production, testing and optimization
• Sample preparation, processing and library preparation for next-generation sequencing and / orsingle cell sequencing
• Participate and support project progression from other department or sites when needed
• Biological sample handling and processing
• Sample staining and acquisition by mass cytometry, flow cytometry, and/or platforms for singlecell sequencing
• Primary data analysis
• SOP development and report writing
• Implementing and maintaining ImmunoScape’s quality control system

• Degree or masters in Life Sciences – biology, immunology, biochemistry, or related subject
• At least 2 years of lab experience
• Experience with handling molecule biology experiments (nucleotide acid extraction, PCR, and next-generation sequencing)
• Prior hands-on experience in protein production (bacterial expression systems, insect cell cultures) and purification (FPLC)
• Experience in cell culture, transient transfection, and lentivirus transfection preferred
• Experience in handling biological materials (human PBMC samples and tissues) preferred
• Experience with flow/mass cytometry or single cell sequencing preferred
• Readiness to learn new techniques and troubleshoot assays
• Rigorous and accountable way of working
• Accurate writing and documentation skills
• Organized and detail-oriented
• Excellent team player, independent, self-driven with good interpersonal skills

About ImmunoScape
ImmunoScape is a pre-clinical biotechnology company focused on the discovery and development of
next- generation TCR cell therapies in the field of oncology. The company’s proprietary Deep
Immunomics technology platform enables highly sensitive, large-scale mining and immune profiling of T
cells in cancer patient samples to identify novel, therapeutically relevant TCRs across multiple types of
solid tumors. ImmunoScape has multiple discovery programs ongoing and will be progressing towards
IND-enabling studies and entry into the clinic.

Key responsibilities – Research Scientist
ImmunoScape is looking for a highly motivated individual with experience in immunology, T cell
functional assays, flow cytometry and cell biology to lead the evaluation, selection and characterization
of TCR-engineered T cells candidates. This position will be located in Singapore.
Key responsibilities include:

• Support the Discovery team in developing internal discovery assets, from early-stage discovery
  efforts to selection of therapeutic candidates
• Establish in vitro testing models to assess T cell anti-tumor activity using cell lines and primary
  cells
• Establish high-throughput in vitro testing models to determine the epitope of a TCR
• Plan, execute, and analyze experiments for the characterization of the safety and activity of TCR-
  engineered T cells
• Author technical documents and report summaries of key experimental data during internal
  meetings and to management

Required qualifications and skills

• A doctoral degree in immunology, biology or related fields, with at least 3 years of lab
  experience
• In-depth experience with functional assessment of T cell activation, proliferation, cytotoxicity is
  required
• Experience with multi-parameter flow cytometry required
• Industry experience in cell therapy and/or immuno-oncology preferred
• Experience with molecular cloning, production and use of viral vectors is a plus
• Ideal candidates should have an extensive track record in designing, planning and delivering on
  project milestones, also evidenced by a very good publication record
• Excellent writing and communication skills, accurate data documentation and reporting skills are
  required
• We expect to recruit an excellent team player who is independent, flexible and self-driven
• Good interpersonal skills are required

• Leading experimental workflows, including planning, testing, optimization and validation for the development of state-of-the art single cell sequencing methods for antigen-specific T celldetection.
• Leveraging immunological, cellular and molecular biology technologies for experiments andassay set-ups
• Data analysis and seamless scientific communication and presentation of experimental designs and results to internal and external stakeholders
• Supervise and manage Research Officers in coordination with ImmunoScape’s Technology and Development team leader
• Documentation and participation in SOP development and technology transfers
• Provide input and help in developing new ideas or methods for ImmunoScape’s technology development roadmap

Required qualifications and skills

• A doctoral degree with publication record in genomics, immunology, biochemistry or related field
• At least 5 years of lab experience with knowledge multi-parameter single cell technologies (flow cytometry, mass cytometry, and/or single-cell sequencing)
• In-depth experience with next-generation sequencing and library preparation is required
• Experience in designing, planning and executing experimental workflows
• Knowledge in T cell biology is preferred
• Ability to thrive and deliver results on goals in a fast-paced, dynamic and highly multi-tasking environment
• Experience in mentoring and supervising other scientists
• Excellent writing and communication skills
• Rigorous, organized and accountable
• Excellent team player, independent, self-driven with good interpersonal skills